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| Glucocorticoid response elements ： ウィキペディア英語版 |
Hormone response element
A hormone response element (HRE) is a short sequence of DNA within the promoter of a gene that is able to bind a specific hormone receptor complex and therefore regulate transcription. The sequence is most commonly a pair of inverted repeats separated by three nucleotides, which also indicates that the receptor binds as a dimer. Specifically, HRE responds to steroid hormones, as the activated steroid receptor is the transcription factor binding HRE. This regulates the transcription of genes signaled by the steroid hormone.
A gene may have many different response elements, allowing complex control to be exerted over the level and rate of transcription.
HRE are used in transgenic animal cells as inducers of gene expression.
==References==
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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